Antibody-based, chemiluminescent or equivalent

Automated immunoassay

FDA-cleared or FDA-approved assays

FDA-cleared or FDA-approved assays, run per the manufacturer's instructions for use

Specimen type, tube and measuring range follow the manufacturer’s package insert, and results are broadly comparable with other laboratories running cleared assays.

How it works

Hormones, proteins, vitamins and tumour markers outside the LC-MS/MS steroid panel, on automated immunoassay analyzers using cleared or approved assays.

On the left, an antibody binds cortisol together with cortisone and structurally related metabolites, producing one blended signal in which cross-reactants are counted as the target, so the result reads falsely high. On the right, liquid chromatography first separates compounds in time, then a mass spectrometer confirms each by a mass-to-charge transition specific to that molecule. — Why the two methods disagree at the level of the molecule.

Reference intervals

Established or verified by the laboratory as CLIA requires. The interval published on the website is the interval the laboratory reports.

FDA-cleared or FDA-approved assays

How it works

Reference intervals

Analytes measured on this platform 29