https://clinicorediagnostics.com/science/library/ Clinical Science Reviews from Clinicore Laboratories. For healthcare professionals. en-us https://clinicorediagnostics.com/science/library/endocrine/androstenedione-testosterone-dht/ https://clinicorediagnostics.com/science/library/endocrine/androstenedione-testosterone-dht/ Testosterone sits in the middle of a metabolic sequence. The ratios between the three androgens encode enzyme activity and androgen source — information a single value cannot carry. Mon, 28 Sep 2026 00:00:00 GMT endocrine https://clinicorediagnostics.com/science/library/endocrine/dhea-vs-dhea-sulfate/ https://clinicorediagnostics.com/science/library/endocrine/dhea-vs-dhea-sulfate/ DHEA-S is an inert reservoir; unconjugated DHEA is the receptor-active, intracrine and neuroactive species. Why the two dissociate, and what the sulfate alone cannot answer. Mon, 28 Sep 2026 00:00:00 GMT endocrine https://clinicorediagnostics.com/science/library/endocrine/estrone-and-estradiol/ https://clinicorediagnostics.com/science/library/endocrine/estrone-and-estradiol/ E1 and E2 are distinct, interconverting estrogens that differ in potency and source. The E2:E1 ratio inverts at menopause and shifts with the route of therapy — and a single value cannot represent either. Mon, 28 Sep 2026 00:00:00 GMT endocrine https://clinicorediagnostics.com/science/library/methods/lc-ms-ms-versus-immunoassay/ https://clinicorediagnostics.com/science/library/methods/lc-ms-ms-versus-immunoassay/ An immunoassay result is a binding estimate; an LC-MS/MS result is a structural measurement. What the peer-reviewed record shows about the difference, and what it costs a patient when the two disagree. Mon, 28 Sep 2026 00:00:00 GMT methods https://clinicorediagnostics.com/science/library/endocrine/small-volume-endocrine-map/ https://clinicorediagnostics.com/science/library/endocrine/small-volume-endocrine-map/ The endocrine system is a connected network, yet it is usually tested one hormone at a time. Multiplexed LC-MS/MS and microsampling change what a single specimen can deliver — and the ratios are what read it. Mon, 28 Sep 2026 00:00:00 GMT endocrine